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With isotretinoin for example, the skin becomes drier (3), the microbiome starts to resemble the composition of bacteria found on atopic skin, with a greater abundance of Staphylococcus and Streptococcus.(4,5)
…TO TOPICAL ONES
If topical benzoyl peroxide is used, the relative abundances of Staphylococcus and Cutibacterium can be reduced, as well as the alpha diversity of the skin microbiome. The number of bacterial species and phylogenetic diversity also decrease after treatment with benzoyl peroxide and tretinoin.(6)