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Atopic Dermatitis

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Skin Barrier Science

A healthy stratum corneum is crucial for optimal skin barrier function. Loss of essential ceramides and reorganisation of intercellular lipids can disrupt the protective skin barrier.¹A growing body of evidence suggests that many dermatologic diseases, including atopic dermatitis, acne vulgaris, psoriasis, and aged, dry skin are associated with altered composition and synthesis of ceramides.²

Furthermore, the literature suggests racial/ethnic variations in skin barrier properties, including ceramide content, stratum corneum structure, and filaggrin mutations.³ Read more about racial/ethnic variations in the skin barrier.

Decrease of Ceramides 1, 3

Decrease of Ceramides 1, 6

Decrease of Ceramides 1, 3, 6

Topical replenishment of ceramides can play a vital role in improving and normalising skin barrier function.¹ Developed with dermatologists, CeraVe is formulated with skin-identical ceramides 1, 3, & 6-II and MVE Technology to restore the skin barrier and provide sustained hydration.

In a randomised, investigator-blind study, 49 women (ages 30-65 years) with dry to very dry skin applied CeraVe Moisturising Cream twice daily on one lower leg for 4 weeks. Skin samples were collected by a dermatologist at baseline and week 4 for lipid analysis.⁴

CeraVe contains a mixture of 3 skin-identical ceramides—ceramide 1, ceramide 3, and ceramide 6-II—plus cholesterol, fatty acids, and phytosphingosine. Together these ingredients have a synergistic effect in repairing the skin barrier.

Slow-release Multivesicular Emulsion (MVE) Technology delivers concentric layers of oil-in-water emulsions. These layers slowly unfold upon application, continually releasing moisturising ingredients for the skin to absorb as needed.

Watch this video to explore the racial and ethnic differences in skin barrier structure and function in patients with dry, atopic skin.

REFERENCES: 1. Sahle FF, Gebre-Mariam T, Dobner B, Wohlrab J, Neubert RH. Skin diseases associated with the depletion of stratum corneum lipids and stratum corneum lipid substitution therapy. Skin Pharmacol Physiol. 2015;28(1):42-55. 2. Coderch L, López O, de la Maza A, Parra JL. Ceramides and skin function. Am J Clin Dermatol. 2003;4(2):107-129. doi:10.2165/00128071-200304020-00004 3. Alexis AF, Woolery-Lloyd H, Williams K, et al. Racial/ethnic variations in skin barrier: Implications for skin care recommendations in skin of color. J Drugs Dermatol. 2021;20(9):932-938. doi:10.36849/jdd.6312 4. Draelos ZD, Baalbaki NH, Raab S, Colón G. The effect of a ceramide-containing product on stratum corneum lipid levels in dry legs. J Drugs Dermatol. 2020;19(4):372-376. doi:10.36849/JDD.2020.4796

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