Ceramide-Containing Regimen Provides Superior Tolerance To Isotretinoin-Induced Side Effects And Skin Barrier Function

Valerie Callender, Carmen Gonzalez, Kanokvalai Kulthanan, Ariana Bitton, Nada Baalbaki

INTRODUCTION

Acne-prone skin is associated with reduced ceramides, elevated transepidermal water loss (TEWL), and skin barrier disruption. As acne becomes more severe, there is an increase in TEWL and significantly reduced free sphingosines and free ceramides.¹ Acne medications compromises skin barrier integrity and lead to side effect and quality of life consequences that results in treatment discontinuation.² Oral isotretinoin is the treatment of choice for patients with severe acne and treatment-resistant moderate acne. Isotretinoin-induced side effects related to dryness are regimen including cleansers and moisturizers supports the skin barrier and isotretinoin-induced side effects.^2,3