The revolution of neuromodulators has transformed the treatment of dynamic expression lines, yet the pursuit of total skin rejuvenation remains a primary goal for aesthetic professionals. Today’s patients present with complex needs—ranging from deep-set static wrinkles to broader issues of skin tone and radiance—requiring solutions that extend the benefits of in-office treatments.

Addressing these multifaceted concerns requires a sophisticated topical bridge. SkinCeuticals P-TIOX is an advanced wrinkle-modulating peptide serum designed to fill this gap. By blending high-potency active ingredients, P-TIOX targets diverse signs of ageing and enhances overall skin health, offering clinicians a dual-purpose tool to augment procedural outcomes or serve as a high-performance standalone therapy

P-TIOX Clinical Study on Anti-Ageing and Skin Quality Improvement (Monotherapy US) 1


This 12-week, double-blinded study involved 89 women aged 25-55 across all Fitzpatrick skin types. Dermatologist evaluations revealed significant improvements across 10 wrinkle attributes after 12 weeks of application
Furthermore, P-TIOX significantly improved critical skin quality attributes such as: 

  • Skin Elasticity: +9.3%
  • Skin Radiance: +10.5%
  • Skin Firmness: +8.4%
  • Skin Smoothness: +16%
  • Overall Skin Condition: +9%
  • Appearance of Pores: -10%
These results demonstrate P-TIOX's ability to visibly reduce multiple signs of ageing and enhance overall skin health, making it an invaluable addition to patient skincare regimens. 

Before/Afters (Green lines shows visual wrinkles using PRIMOS methodology) 

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P-TIOX Integrated Skincare Study with Neuromodulator Injection 2^



This split-face study evaluated P-TIOX's ability to improve skin quality in difficult-to-inject areas and enhance the effects of Neuromodulators on crow's feet and glabellar lines. The study involved 40 male and female subjects (ages 37-70, Fitzpatrick I-VI). 
Results demonstrated a greater statistically significant improvement in 18 contraction wrinkles and facial attributes on the side treated with P-TIOX compared to the vehicle side, 8 weeks after injection with neuromodulators. This shows that P- TIOX effectively complements and amplifies the benefits of neuromodulator injections, leading to improved patient satisfaction and superior outcomes, particularly in areas challenging to treat with injectables alone. 

P-TIOX is formulated with a potent blend of ingredients, each contributing to its comprehensive anti-aging and skin-improving benefits: 


  • 2% Acetyl Hexapeptide-8 (Amplified Argireline): Addresses dynamic wrinkles by interfering with muscle contractions. 
  • 2% Dipeptide Diaminobutyroyl Benzylamide Diacetate: Works synergistically with Acetyl Hexapeptide-8 to reduce expression lines and boost collagen. 
  • 5% Polyhydroxy Acid (PHA): Provides gentle exfoliation and moisturizing benefits for improved skin texture and radiance. 
  • 5% Niacinamide: Enhances skin barrier function, repairs, and reduces the appearance of crow's feet. 
  • 1% Laminaria Digitata Extract: Stimulates collagen synthesis, improving the structural integrity of the skin. 

Learn More

  1. A 12-week, single center clinical study was conducted on 75 females with Fitzpatrick type I-VI, (50% of subject with sensitive skin), ages 25-55 and mild to moderate wrinkles, fine lines, pore appearance, rough skin texture evaluated by dermatologist. Efficacy evaluations were conducted at baseline, week 1, week 2, week 4, week 8 and week 12.
  2. A 10-week, split-face, double-blind, randomized controlled study was conducted on 40 male and female subjects (Fitzpatrick I-VI), ages 38-70, presenting with mild-to-moderate facial lines and rough skin. Following a randomized application of either neuropeptide serum or vehicle in conjunction with a standard cleanser and moisturizer, all subjects received BTX-A injections to the glabella and lateral canthal lines. Clinical efficacy was assessed via live grading at baseline and weeks 2, 4, and 8 to evaluate the serum's impact on 19 facial attributes and difficult-to-inject areas.
  3. Lupin, M. (2024) ‘Full supplement: Real-world clinical experience combining a neuro-peptide serum and botulinum toxin type-A injections’, Journal of Drugs in Dermatology, 23(11). doi:10.36849/jdd.436610.

*HermaS. Global Aesthetics Consensus: Botulinum Toxin Type A—Evidence-Based Review, Emerging Concepts, and Consensus Recommendations for Aesthetic Use, Including Updates on Complications, Herma Sundaram

^P-TIOX is a cosmetic skincare product for topical use. Do not inject.