Recent advances in skin barrier research: From basic science to clinical discovery

INTRODUCTION

The human skin barrier, as the first line of defense against external aggressors and the essential modulator of our body’s internal homeostasis, has been studied extensively. During the past few years, with the emergence of new discoveries and scientific evidence, this field has been updating in a highly dynamic manner. The shift of biochemical compositions,especially epidermal ceramides and essential lipids, the alteration of key biomarkers under environmental damage, and the clini- cal manifestation of compromised skin barrier (eg, xerosis, atopic dermatitis, etc) are all at the center stage for investigation. More importantly, it has become extremely critical to provide effective prevention and treatment routines for patients of all skin types who are suffering from impaired skin barrier.

Qian Zheng MD PhD, Charbel Bouez PhD