The efficacy of a salicylic acid-containing cleanser and urea-containing cream on rough and bumpy skin

INTRODUCTION

Keratosis pilaris (KP) is a keratinization disorder that manifests as rough, bumpy skin on the proximal, lateral surface of the extremities, the face, and the buttocks. It is characterized by reduced skin barrier function, leaving the skin dry in many and with exacerbated symptoms in winter for most. While KP phenotype is asymptomatic, it is chronic and can be embarrassing and frustrating for many. An effective treatment for KP should address the spiny keratinous follicular plugs and follicular erythema, but there are limited options that address both while still being aesthetically suitable for long term application. Hyperkeratotic skin can benefit from topical formulations that hydrate to soften keratin, promote desquamation, and help to restore skin barrier function. Herein, we describe the efficacy evaluations for a Cleanser and a Cream that contain keratolytic agents, moisturizing ingredients, and ceramides on dry, rough and bumpy skin, including KP. To complement clinical assessment, a 3D image-based analysis was employed to assess the texture of skin with KP.

Petra Staubach, Nada Baalbaki, Iqra Iqbal, Margarita Yatskayer, Gene Colón