How can we manage epidermal wound healing in private practice?

  • 15min
  • May. 2022
  • Supported By
    • La Roche-Posay

Wound healing is a natural restorative response to tissue injury with a complex cascade of cellular events resurfacing, reconstituting, and restoring the tensile strength of injured skin. Any interruption in the natural cascade can disrupt subsequent phases and potentially result in abnormal healing, chronic wounds, and eventual skin lesions.1

Different areas of wounds can be in different phases of healing.1



A topically applied emulsion can accelerate the natural restorative response of epithelialization in wound healing.1

During healing, skin can be painful, pruritic, or tugging.2 Most patients experience erythema, desquamation and cracks, as well as subjective symptoms like burning and tingling sensations, pain or pruritus.3

Simple techniques such as maintaining a clean but moist wound environment with occlusive dressings help to accelerate re-epithelialization and alter the inflammatory milieu to favor better healing.5



Why should you prescribe an epidermal repairing skincare?


Some types of skin lesions can require a topically applied healing care :2

Many skin lesions/skin may not heal easily either because of the severity of the wounds or the individual’s poor state of health. Any wound that does not heal within a few weeks should be examined by a healthcare professional because it might be infected, reflect an underlying disease such as diabetes, or require medical treatment.1

Bibliography

  1. Gantwerker EA, Hom DB "Skin: histology and physiology of wound healing." Facial Plast Surg Clin North Am. 2011 Aug;19(3):441–53.
  2. Henderson J, Ferguson MW, Terenghi G. "The feeling of healing." Plast Reconstr Surg. 2012 Jan;129(1):223e-224e.
  3. Rougier A, Humbert P. Clinical efficacy on epidermal wound healing of topically applied madecassoside associated with copper/zinc/manganese salts. JAAD, February 2008 Volume 58, Issue 2, Supplement 2, Page AB144.
  4. Crickx b. et al. A French observational study on the management of epidermal wound healing. JAAD, May 2016, Volume 74, Issue 5, Supplement 1, Page AB90
  5. Sun BK, Siprashvili Z, Khavari PA. Advances in skin grafting and treatment of cutaneous wounds. Science. 2014 Nov 21;346(6212):941-5.
  6. Liu M, Dai Y, Li Y. Luo Y. Huang F. Gong Z. Meng, Q. Madecassoside isolated from Centella asiatica herbs facilitates burn wound healing in mice. Planta Med. 2008;74:809–815.
  7. Bylka W, Znajdek-Awiżeń P, Studzińska-Sroka E, Brzezińska M. Centella asiatica in cosmetology. Postepy Dermatol Alergol. 2013 Feb;30(1):46-8.
  8. Cao W, Li XQ, Zhang XN, Hou Y, Zeng AG, Xie YH, Wang SW. Madecassoside suppresses LPS-induced TNF-alpha production in cardiomyocytes through inhibition of ERK, p38, and NF-kappaB activity. Int. Immunopharmacol. 2010;10:723–729.
  9. Jung E et al. Madecassoside inhibits melanin synthesis by blocking ultraviolet-induced inflammation. Molecules. 2013 Dec 16;18(12):15724–36.
  10. Proksch E et al. "Topical use of dexpanthenol: a 70th anniversary article." J Dermatolog Treat. May 14, 2017:1–8.