Seborrheic dermatitis (SD) is considered one of the most frequent dermatoses. Correctly diagnosing SD is essential, as it can sometimes be mistaken for other dermatological conditions like psoriasis, atopic dermatitis, or even dandruff. Misdiagnosis may lead to inappropriate treatments, resulting in prolonged suffering for patients. Therefore, a thorough understanding of the clinical presentation, risk factors, and differential diagnoses is crucial. This article will explore the latest scientific and medical data on SD, including its risk factors, etiology, impact on Quality of Life, diagnostic, and pathophysiology. This article will also present the available evidence-based treatments, and guidelines for patient education and long-term management to empower both healthcare professionals and patients in effectively dealing with this chronic skin condition.