Acne vulgaris is a chronic inflammatory skin disease with a multifactorial pathogenesis. The principal actors are the sebaceous gland, keratinocytes of the follicle, Cutibacterium acnes and the skin microbiome/innate immunity. Dermocosmetics (DC) play more and more frequently a role as adjuvants to pharmacological treatments to mitigate side effects, as stand-alone products in the maintenance after an initial treatment with pharmacologically active treatments or in the management of mild acne. The tested DC serum contains salicylic acid, glycolic acid, niacinamide and lipohydroxy acid.