Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit. Adult female acne lesions are mainly observed on the mandibular and peri-oral region. An important feature in the aetiology of acne is the presence of pilosebaceous ductal hypercornification or microcomedones. Moreover, a significant correlation between the severity of acne and the number and size of microcomedones has been observed. An adequate therapeutic management of acne should always include a maintenance regimen to prevent recurrences after discontinuing a successful treatment.