INCREASED SKIN PH AND TRANSEPIDERMAL WATER LOSS MAY SERVE AS PREDICTOR FOR ATOPIC DERMATITIS FLARES

 

Atopic dermatitis (AD) is a common, chronic relapsing skin disease, characterized by periods of disease flare, followed by periods of remission. Alterations in epidermal barrier function have been shown to play a key role in pathogenesis of AD. Trans-epidermal water loss and skin pH are important indicators for skin health with an important role of skin pH as a regulator of the epidermal barrier homeostasis and of the skin microbiome diversity. Skin pH plays also a role in desquamation, permeability, and stratum corneum cohesion. To demonstrate the relationship between epidermal barrier alteration and clinical manifestation of AD, a longitudinal study monitoring both epidermal barrier function and AD severity has been performed