Atopic dermatitis beyond the skin: impact of skin pain in the Scars of Life project

Nov 2025
10min

PUBLISHED IN

JAAD International

AUTHORS

Jonathan I. Silverberg, Pr, Roberto Takaoka, Pr, Jerry Tan, Pr, Thomas Luger, Pr, Chaoying Gu, Pr, Roni Dodiuk-Gad, Pr, Flavia Pretti Aslanian, Pr, Cita Rosita Sigit Prakoeswa, Pr, Bruno Halioua, Dr, Ann’Laure Demessant Flavigny, PhD, Caroline Le Floc’h, PhD, Nabil Kerrouche, PhD, Stéphanie Merhand, PE, Wendy Smith Begolka, PE, África Luca de Tena Smith, PE, Shulamit Burstein, PE, Delphine Kerob, Dr, Charles Taieb, Dr, Charbel Skayem, Dr, Therdpong Tempark, Pr, Abraham Getachew Kelbore, Dr, Julien Seneschal, Pr, Alexander Stratigos, Pr, Martin Steinhoff, Pr, Laurent Misery

INTRODUCTION

Skin pain (SP) is increasingly recognized as a significant symptom in atopic dermatitis (AD) (1). It is associated with discomfort, increased disease burden, and reduced quality of life (QoL) (2). Although the nature of SP in AD remains poorly understood due to limited systematic research, patients report pain, discomfort, and sensitivity, suggesting possible peripheral and central sensitization (3). As part of the Scars of Life project, we conducted a cross-sectional observational study across 27 countries on five continents. A representative sample was selected in each country using the quota method.

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