MACULOPAPULAR RASH


TYPE OF TREATMENT PROACTIVE
(PREVENTION/STEP 0) 		REACTIVE
(MANAGEMENT IN CASE OF AE)
    Targeted therapy (BRAF inhibitors)

    Conventional chemotherapy
  • Antimetabolites (5-FU etc.)
  • Alkylating agents (cyclophosamide, cisplatin)
  • Mitotic inhibitors (taxanes, vinca alkaloids)
    • Immunotherapy (immune checkpoint inhibitors, anti-Nectin 4)
  • Emollients “plus” balm, able to rebalance microbiome, with key ingredients such as shea butter, niacinamide, and/or ceramides
  • Moisturizers with key ingredients such as shea butter, niacinamide, ceramides
  • Sunscreen with UV broad spectrum UVA/UVB filters to prevent possible PIH in darker phototypes
  • Continue Step 0
  • Camphor-menthol-hydrocortisone cream
  • Topical antipruritics
  • TCS (once-twice per day for a maximum of 4 weeks)
  • Oral antihistamines
  • Oral corticosteroids for grade 3 toxicities
  • Oncologist may suspend or alter treatment at grade 3; resume after 2 weeks if rash has faded to 0-1
  • Grade 4, admit to hospital