- Targeted therapy (EGFR inhibitors, MEK inhibitors, FGFR inhibitors, BRAF inhibitors, PI3K inhibitors)
- Cytotoxic chemotherapy
- Radiation therapy
- Immune checkpoint inhibitors
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- Initiate at same time as cancer treatment
- Gentle cleanser close to skin PH with lipid replenishing ingredient
- Moisturizers, including moisturizers able to maintain diverse skin microbiome (emollient “plus”), with key ingredients such as shea butter, niacinamide, and/or ceramides
- Apply moisturizer to face, hands, feet, neck and back daily plus re-apply as needed
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- Gentle cleanser close to skin PH with lipid replenishing ingredient
- Emollients “plus” balm, able to rebalance microbiome, with key ingredients such as shea butter, niacinamide, and/or ceramides
- Preferred formulas: moisturizing cream and balms
- Ureas 3-10% in case of severe xerosis; avoid in red/irritated areas and with radiation dermatitis
- Hydrating lip balms, preferably with sunscreen
If eczematiform eruption:
- TCS/TCI once-txice per day (maximum of 4 weeks for TCS) might be needed if pruritus uncontrolled by dermocosmetics
- Antihistamines
- GABA agonist
- Doxepin/aprepitant/antidepressants
- TENS or acupuncture
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