Acute generalized exanthematous pustulosis (AGEP)

    La Roche-Posay
  • May 2022
  • 5min

Therapeutic classes inducing this adverse event
Antiangiogenic agent, BRAF inhibitor, CTLA4 inhibitor, Chemotherapy, Cyclin-dependent kinase 4/6 inhibitor, EGFR inhibitor, Hormone therapy, KIT inhibitor, MEK inhibitor, PD-1 inhibitor, RAF inhibitor, Radiotherapy, SMO inhibitor, mTOR inhibitor

Acute generalized exanthematous pustulosis
Widespread erythema with superficial micropustules, predominantly in skin folds, fever, increased neutrophils
Widespread erythema with superficial micropustules, predominantly in skin folds, fever, increased neutrophils

SIMPLIFIED GRADING

No immediate life-threatening consequences


REFERENCES

Peuvrel L, Cassecuel J, Bernier C, Quéreux G, Saint-Jean M, Le Moigne M, Frénard C, Khammari A, Dréno B; Supported by GESTIM Nantes group of cutaneous adverse events induced by cancer treatments. TOXICAN: a guide for grading dermatological adverse events of cancer treatments. Support Care Cancer. 2018;26:2871-7.

SIMPLIFIED GRADING

Life-threatening consequences from decompensation of underlying condition


REFERENCES

Peuvrel L, Cassecuel J, Bernier C, Quéreux G, Saint-Jean M, Le Moigne M, Frénard C, Khammari A, Dréno B; Supported by GESTIM Nantes group of cutaneous adverse events induced by cancer treatments. TOXICAN: a guide for grading dermatological adverse events of cancer treatments. Support Care Cancer. 2018;26:2871-7.

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