Hyperkeratotic hand-foot syndrome

    La Roche-Posay
  • May 2022
  • 15min

Therapeutic classes inducing this adverse event
BRAF inhibitor, Antiangiogenic agent

Hyperkeratotic hand-foot syndrome
Hyperkeratosis of support points
Hyperkeratosis of support points

SIMPLIFIED GRADING

Painless


References

Peuvrel L, Cassecuel J, Bernier C, Quéreux G, Saint-Jean M, Le Moigne M, Frénard C, Khammari A, Dréno B; Supported by GESTIM Nantes group of cutaneous adverse events induced by cancer treatments. TOXICAN: a guide for grading dermatological adverse events of cancer treatments. Support Care Cancer. 2018;26:2871-7.

SIMPLIFIED GRADING

Moderate pain (VAS <6) or blistering or limiting instrumental ADL


References

Peuvrel L, Cassecuel J, Bernier C, Quéreux G, Saint-Jean M, Le Moigne M, Frénard C, Khammari A, Dréno B; Supported by GESTIM Nantes group of cutaneous adverse events induced by cancer treatments. TOXICAN: a guide for grading dermatological adverse events of cancer treatments. Support Care Cancer. 2018;26:2871-7.

SIMPLIFIED GRADING

Severe pain (VAS ≥ 6) OR Widespread blistering OR Limiting self care ADL, difficulty walking


References

Peuvrel L, Cassecuel J, Bernier C, Quéreux G, Saint-Jean M, Le Moigne M, Frénard C, Khammari A, Dréno B; Supported by GESTIM Nantes group of cutaneous adverse events induced by cancer treatments. TOXICAN: a guide for grading dermatological adverse events of cancer treatments. Support Care Cancer. 2018;26:2871-7.

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