Mechanoreceptor activation from topical treatments modulates the sensorial perception of our skin

S. Connetable, S. Hendrickx-Rodriguez, B. Lynch, J. Pace, G. S. Luengo, R.H. Dauskardt, A. Potter

INTRODUCTION

Perception of sensorial experiences arises from the mechanical stimulation of mechanoreceptors located below the skin surface and activation of afferent neurons which carry signals to the central nervous system. The objective of this study was to develop an in vitro/in vivo/in silico framework to understand factors that contribute to the perception of skin tightness. We then use this knowledge to develop an optimized moisturizing formula capable of minimizing skin discomfort while still providing typical skin care benefits of a moisturizer.