Enhanced efficacy of a topical antioxidants regimen in conjunction with a home use non ablative fractional diode laser in photo-damaged facial skin

Abstract

Background: Photodamaged facial skin is characterized by fine lines and wrinkles, mottled pigmentation, and other changes.

Objective: To evaluate and compare the efficacy and tolerance of a home-use laser device when used alone or in combination with an antioxidant facial treatment for moderate photodamage.

Methods: This was a 49 subjects, evaluator-blinded, split-face, randomized, single-center, 24- week, two-phase, study. In Phase 1, all subjects treated one facial side with test products and a home-use laser device and the other side of the face with laser alone for 12 weeks, followed by, a 2-week regression period during which they used only support materials. For phase 2 all subjects were divided into 2 independent treatment groups. For the next 10 weeks subjects of first group treated the assigned facial side with test products and support materials and the other facial side with only support materials. Subjects in the second group treated their entire face with only support materials. Efficacy and tolerance were assessed by clinical grading, VISIA CR imaging, and self-assessment questionnaires.

Results: The combination of laser and test products improved all photodamage parameters evaluated.

Conclusion: The test products enhanced and prolonged clinical benefits obtained with the laser alone.

Roy Geronemus, Ana Du, Margarita Yatskayer, Stephen Lynch, Yevgeniy Krol & Christian Oresajo