A dermocosmetic associated with a fixed combination of adapalene 0.1% and benzoyl peroxide 5% helps to protect the skin barrier in mild to moderate acne

INTRODUCTION

Acne is a chronic inflammatory skin condition associated with non-inflammatory lesions, inflammatory lesions and an altered skin barrier that can even be worsened by acne medications.
The pathophysiology of acne is complex and multifactorial, comprising a peripheral hormonal factor and chronic stimulation of the innate immunity by commensal bacteria (Cutibacterium. acnes and Staphylococcus epidermidis) of the microbiome with a loss of diversity, as well as other internal and external factors called exposome factors.
The role to dermocosmetics in acne has become a topic of interest to physicians taking care of acne patients. Over-the-counter acne skincare is proposed to either manage milder forms of acne as a monotherapy of improve efficacy and/or improve tolerability of acne medications for an optimal compliance and patient satisfaction.
The tested dermocosmetic (herafter ND) is a skin care developed for acne prone skin. The lightweight cream is easily absorbed and targets acne lesions whilst revitalizing and hydrating skin for up to 24 hours.
ND skin care targets all acne pathogenic factors thanks to key ingredients such as salicylic acid 2% for exfoliating/comedolytic action, phyco-saccharide 2% to decrease sebum production, and vitamin CG to decrease inflammation, as well as ingredients that enable regeneration of the disrupted skin barrier such as mineralizing water 60%, Bifida ferment lysate 1%, and hyaluronic acid 0.2%.

Brigitte Dréno, Amir Khammari, Karine Duhamelle, Catherine Delva, Delphine Kerob