M89, a dermocosmetic combining 89% Vichy volcanic mineralizing water and hyaluronic acid does not modify cutaneous penetration of topical ivermectin ex vivo

INTRODUCTION

Rosacea is a chronic inflammatory dermatosis with an unpredictable course and characteristic features of persistent erythema associated with periodic intensification or ‘flares’.Clinical trials with ivermectin 1% cream have demonstrated greater rapidity and overall superiority in decreasing inflammatory lesions when compared to vehicle in papulopustular rosacea. M89 (Mineral 89, Laboratoires Vichy) contains 89% of Vichy volcanic mineralizing water (VVMW) a volcanic mineralizing water, and 0.4% hyaluronic acid (HA), an extracellular matrix component with viscoelastic and hygroscopic properties, and is able reinforce skin barrier and improve signs and symptoms in rosacea among other indications. VVMW is highly enriched in minerals which strengthen the skin’s natural defenses, e.g. restoring the skin barrier, and enhancing innate immunity. In vitro and in vivo studies showed that VVMW induced a statistically significant increase (p<0.05) in catalase enzyme activity. These primary antioxidant enzymes convert 2 potentially harmful reactive oxygen species: superoxide and hydrogen peroxide, to water. It has also been shown to have anti-inflammatory activity.In vitro and in vivo studies on VVMW have confirmed its potential to reinforce skin barrier function and even accelerate skin barrier recovery. Salsberg et al. showed that M89 was very well tolerated, with no reported safety issues and was very much appreciated by subjects with sensitive skin and investigators. Moreover, results from a large, international observational study showed that M89 significantly improves skin signs and symptoms after 4 weeks of continued use with no tolerance issues in subjects with dermatological conditions such as rosacea, sensitive and reactive skin, as well as in subjects who had recently undergone esthetic procedures. M89 was well-tolerated and had high subject satisfaction.

Jerry Tan, Magali Breisse, Emilie Raynaud, Noémie Merle, Ingrid Durand, Sebastien Gregoire, Laurène Roussel-Berlier, Delphine Kerob