Purpose: Tretinoin is a topical gold standard for photoaging treatment. However, patient adherence can be impaired by local tolerability in the first 1–2 weeks of treatment. Mineral 89 Probiotic Fractions® (M89PF) containing Vichy volcanic mineralizing water®, probiotic fractions, hyaluronic acid, niacinamide and tocopherol was developed to fulfill the need for adjunctive products that can reinforce skin barrier and manage retinoid induced irritation.
Patients and Methods: The study included 38 women, aged 44–60 years, phototype II–VI, applying 0.025% tretinoin gel once nightly for 84 days. For 28 days, one hemi face was treated with M89PF and sunscreen SPF 50+ while other hemi face received sunscreen only. Then, M89PF application was changed to full face. Evaluations were performed at days 0, 7, 28 and 84. Erythema, dryness, fine lines, skin tone, radiance and pore appearance were assessed by a dermatologist. Tolerability was evaluated through selfassessment questionnaire. Skin hydration levels, inflammatory and oxidative stress biomarkers were analyzed by immunological assay: Interleukin(IL)-8, IL1-alpha, IL1-Receptor Antagonist (IL-1Ra), Prostaglandin E2 (PGE2), Catalase and Superoxide Dismutase (SOD).
Keywords: skin barrier, irritation, Vichy volcanic mineralizing water®, hyaluronic acid, niacinamide, tocoferol
Camila VALPAÇOS, Stéphanie LECLERC-MERCIER, Luana LOPES, Diego SVOBODA, Daniele MIRANDA, Priscila CORREIA, José JUNIOR, Erika FERNANDES, Veronique FRANCOIS-NEWTON, Madiiha Bibi MANDARY, Audrey GUENICHE, Jerry TAN, Delphine KEROB