A novel dermocosmetic routine containing Vitamin B3 and 2-Mercaptonicotinyl Glycine significantly improves melasma after 3 months of daily use and provides a similar treatment outcome after 6 months compared to a 3 -month treatment course following a switch from a 3-month treatment with a Kligman triple formula

INTRODUCTION

Melasma is a common chronic refractory pigmentation disorder.¹
Kligman triple formula (KT; fluocinolone, tretinoinand hydroquinone) is consideredthemosteffectiveapproachbut hasitslimitations.²
A dermocosmetic serum containing Vitamin B3 and 2-MercaptonicotinylGlycine was developed for melasma.

k identified specific cosmetic ingredients able to target both HIF-1 – degrading enzymes simultaneously and to maximize the activation of the HIF-1α pathway.