Melanin production inhibitors currently marketed tyrosinase, the rate limiting enzyme in melanin synthesis process. Yet only a few have demonstrated clinical efficacy while some present safety issues.

Hyperpigmentation disorders are a frequent reason for dermatology consultations as they can impair quality of life.

Minimally invasive aesthetic procedures, such as microneedling and non-ablative laser treatment, are rapidly increasing in popularity due to minimal recovery and downtime with effective results for skin rejuvenation.

Pigmentary disorders (PD) such as Melasma, Post-inflammatory Hyperpigmentation (PIH), Solar Lentigo, Peri-Orbital Hyperpigmentation (POH) and Axillary Hyperpigmentation (AH) are frequent dermatological conditions, but little is known on their real-world prevalence and impact.